Platform Randomised trial of INterventions against COVID-19 In older peoPLE - PRINCIPLE
Participant Registration
Screening Form
Thank you for considering participating in the PRINCIPLE trial.
If you have not already read the Participant Information Leaflet you can download it by clicking the link below.
Click here to download the PRINCIPLE Participant Information Leaflet
There is also an illustrated summary of the Participant Information Leaflet that you can download by clicking the link below:
Click here to download an illustrated summary of the PRINCIPLE Participant Information Leaflet
Click here to access translated versions of the PRINCIPLE Participant Information Leaflet
To start your registration, please complete this screening form.
After you have answered all the questions on this form
please click the "Submit" button at the bottom of the page to proceed to your Consent Form
Are you willing to give informed consent for participation in the study?
Do you have a new continuous cough, and/or high temperature, and/or a loss of or change in your normal taste or sense of smell, which have been present for less than 15 days?

Defined:
A new continuous cough - this means coughing a lot for more than an hour, or 3 or more coughing episodes in 24 hours (if you usually have a cough, it may be worse than usual)
and/or
A high temperature - this means you feel hot to touch on your chest or back
(you do not need to take your temperature)

What date did you start to feel unwell with this illness?
- -
Are you feeling almost recovered from this illness (i.e. generally much improved and your symptoms are now mild or almost absent)?
Have you had a positive test for COVID-19 infection?
What date was this COVID-19 test taken?
- -
Are you unwell with symptoms of COVID-19?
These symptoms may include, but are not limited to, shortness of breath, general feeling of being unwell, muscle pain, diarrhoea and vomiting.
What date did you start to feel unwell with this illness?
- -
Are you feeling almost recovered from this illness
(i.e. generally much improved and your symptoms are now mild or almost absent)?
Are you aged 65 years old or over?

Are you aged 50 to 64 years old with at least one of the comorbidities/conditions listed below?

  • weakened immune system due to a serious illness or medication (e.g. chemotherapy)
  • heart disease or high blood pressure
  • asthma or lung disease
  • known diabetes
  • liver disease
  • stroke or neurological problem

Are you aged 50 to 64 years old
and have a body mass index (BMI) at or above 35 kg/m2?

Click here if you need to calculate your BMI
Are you pregnant or planning on becoming pregnant within the next few weeks?
Are you breastfeeding or planning on starting during the course of the trial?
Do you have myasthenia gravis (a rare type of neuromuscular disorder)?
Are you currently admitted in hospital?
Have you previously participated in the PRINCIPLE trial?
Are you currently taking antibiotics for a recently diagnosed illness?
Have you had a previous adverse reaction to doxycycline or any other tetracyclines
(e.g. lymecycline, chlortetracycline, minocin/minocycline, oxytetracycline or tetracycline)?
Are you currently taking doxycycline or any other tetracyclines
(e.g. lymecycline, chlortetracycline, minocin/minocycline, oxytetracycline or tetracycline)?
Sucrose intolerance (i.e. rare hereditary problems of fructose intolerance, glucose galactose malabsorption or sucrose-isomaltase insufficiency)?

Are you currently taking any of the following drugs?

Conditions have been provided for the most common uses of these drugs, but these drugs may be used for other conditions not listed here. If you take any of these drugs for any reason, even if not listed here, please respond with "Yes".

commonly used to treat athritis or psoriasis:
  • Ciclosporin
commonly used to treat psoriasis:
  • Retinoids (e.g. acitretin, alitretinoin, isotretinoin, tretinoin)
commonly used for chemotherapy:
  • Methotrexate
commonly used to treat migraines:
  • Ergotamine
commonly used to treat pain:
  • Methoxyflurane
commonly used to treat bipolar or major depressive disorder:
  • Lithium
Do you have systemic lupus erythematosus?
Do you have a known allergy to inhaled corticosteroids?
Are you currently prescribed corticosteroids by inhaler, by mouth or had a corticosteroid injection in the past month?

Do you have any of the following conditions:

  • Galactose intolerance
  • Lapp lactase deficiency
  • Glucose-galactose malabsorption
Where did you hear about the trial?
If other, please specify
After you have answered all the questions on this form and clicked "I'm not a robot" below
please click the "Submit" button at the bottom of the page to proceed to your Consent Form
PRINCIPLE Participant Registration v9.2 02-12-2020
REC Number: 20/SC/058, IRAS Number: 281958, EudraCT Number: 2020-001209-22, Chief Investigator: Professor Christopher Butler