Platform Randomised trIal of treatmeNts in the Community
for epIdemic and Pandemic iLlnEsses - PRINCIPLE
Participant Registration
Screening Form
Thank you for considering participating in the PRINCIPLE trial.
If you have not already read the Participant Information Leaflet you can download it by clicking the link below.
Click here to download the PRINCIPLE Participant Information Leaflet
There is also an illustrated summary of the Participant Information Leaflet that you can download by clicking the link below:
Click here to download an illustrated summary of the PRINCIPLE Participant Information Leaflet
Click here to access translated versions of the PRINCIPLE Participant Information Leaflet
To start your registration, please complete this screening form.
After you have answered all the questions on this form
please click the "Submit" button at the bottom of the page to proceed to your Consent Form
Please select your age range
Are you willing to give informed consent for participation in the study?
Have you had a positive test for COVID-19 infection?
What date was this COVID-19 test taken?
- -
What type of COVID-19 test was taken?
(PCR or Lateral flow) Lateral flow if result received within 30 mins.
Are you unwell with symptoms of COVID-19?
These symptoms may include, but are not limited to, a new continuous cough, and/or high temperature, and/or a loss of or change in your normal taste of sense of smell, sore throat, shortness of breath, general feeling of being unwell, muscle pain, diarrhoea and vomiting.
What date did you start to feel unwell with this illness?
- -
Are you feeling almost recovered from this illness
(i.e. generally much improved and your symptoms are now mild or almost absent)?
Are you currently admitted in hospital?
Have you previously participated in the PRINCIPLE trial?

Are you a pre-menopausal female?

This includes women on any type of contraception; women who are single; women whose husbands have been vasectomized or whose husbands have received or are using other contraceptive devices.

Are you using a highly effective method of contraception* and prepared to use this for the 28 days of the study?

* The implant, the coil and male or female sterilisation will be acceptable for participating in the trial. The injection and most forms of hormonal contraception will also be considered acceptable for the trial, if used in combination with condoms or other barrier methods. However, condoms alone won’t be sufficient during the study.
You can discuss any questions you have about contraception during the study period with the trial team.
Are you pregnant or planning on becoming pregnant within the next few weeks?
Are you breastfeeding or planning on starting during the course of the trial?
Do you have a female sexual partner who is pre-menopausal and capable of becoming pregnant?

Is your female sexual partner using a highly effective method of contraception* and prepared to use this for the 28 days of the study?

* The implant, the coil, and male or female sterilisation will be acceptable for participating in the trial. The injection and most forms of hormonal contraception will also be considered acceptable for the trial, if used in combination with condoms or other barrier methods. However, condoms alone won’t be sufficient during the study.
You can discuss any questions you have about contraception during the study period with the trial team.
Do you have severe liver disease?
Do you have a known allergy to favipiravir?
Are you currently taking favipiravir?
Do you have a known history of gout?
Are you willing to not eat or drink grapefruit juice for 14 days?

Are you hypersenitive/allergic to any of the following:

  • Ivermectin
  • Colloidal silicon dioxide
  • Croscarmellose sodium
  • Magnesium stearate
  • Microcrystalline cellulose
  • Pregelatinized starch

Have you ever travelled to countries that are endemic for Loa loa?

(Angola, Cameroon, Central African Republic, Chad, Democratic Republic of Congo, Ethiopia, Equatorial Guinea, Gabon, Republic of Congo, Nigeria and Sudan)
Do you have a known bleeding disorder?

Are you currently taking the following drugs:

  • Quinidine
  • Amiodarone
  • Diltiazem
  • Spironolactone
  • Verapamil
  • Clarithromycin
  • Erythromycin
  • Itraconazole
  • Ketoconazole
  • Cyclosporine
  • Tacrolimus
  • Sirolimus
  • Indinavir
  • Ritonavir
  • Cobicistat
  • Warfarin
Where did you hear about the trial?
If other, please specify
After you have answered all the questions on this form and clicked "I'm not a robot" below
please click the "Submit" button at the bottom of the page to proceed to your Consent Form
PRINCIPLE Participant Registration v18.0 20-07-2021
REC Number: 20/SC/058, IRAS Number: 281958, EudraCT Number: 2020-001209-22, Chief Investigator: Professor Christopher Butler